Swiftly attain sections as skinny or thick as your application involves, with no stressing about losing or distorting beneficial tissue samples.
Megatome is usually a vibrating microtome designed to segment a broad array of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With higher blade vibrating frequency and minimized blade deflection, Megatome allows substantial-throughput tissue sectioning with uniform floor profile, together with negligible tissue damage and information loss.
Antibodies may possibly consider weeks to diffuse by means of just a few millimeters of tissue, using a steep labeling gradient from surface area to core.
Megatome is made for accuracy: the blade vibrates at a greater frequency and larger amplitude range than other microtomes, and features a unique deflection control system.
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Our preformulated EasyIndex Remedy raises and homogenize the refractive index of delipidated tissue samples, rendering them completely clear. This permits light-weight penetration into the sample and makes sure the acquisition of significant-resolution, in-emphasis picture data.
Megatome is often a novel microtome that permits for top-precision sectioning of a wide array of tissue samples – from organoids, to arrays of animal organs, to intact human brain hemispheres – with negligible tissue injury and information reduction.
eFLASH is really a immediate tissue labeling approach that allows for uniform total-organ staining in 20 rounds of labeling.
Fully delipidate complete mouse brains or comparably sized samples in just one working day with SmartBatch+, or in a single week with our passive clearing package.
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SHIELD avoids the variability of hydrogel embedding and the information decline from PFA preservation, shielding specimens for various rounds of processing.
Leverage the Apparent+ tissue clearing technique, coupled with eFLASH and patented stochastic electrotransport technologies, to fast very clear and label whole organs. Vital highlights and capabilities include things like:
Our novel Defend tissue preservation system kinds intramolecular bonds applying polyfunctional, versatile epoxides to stabilize tissue architecture and safeguard the sample’s endogenous fluorescence, protein antigenicity and nucleic acids.